High pregnancy rates with administration of granulocyte colony-stimulating factor in ART-patients with repetitive implantation failure and lacking killer-cell immunglobulin-like receptors
نویسندگان
چکیده
WolfgangWürfel , Claudia Santjohanser, Kaimo Hirv , Monika Bühl , OsamaMeri , Ina Laubert , Irene von Hertwig , Klaus Fiedler, Jan Krüsmann and Gottfried Krüsmann Kinderwunsch Centrum München (KCM) (Fertility Center Munich), Lortzingstr.26, D-81241 München (Munich), Germany Zentrum für Humangenetik und Laboratoriumsmedizin (Center for Human Genetics and Laboratory Medicine), Lochhamer St. 29, D 82152 Martinsried, Germany *Correspondence address. Tel: +49-89-244144-99/91; Fax: +49-89-244144-41/42; E-mail: [email protected] doi:10.1093/humrep/deq106 Advanced Access publication on June 3, 2010
منابع مشابه
Does Subcutaneous Administration of Granulocyte Colony Stimulating Factor Improve Pregnancy Outcome in Patients Undergoing Intracytoplasmic Sperm Injection?
Background:Expression of granulocyte colony stimulating factor (G-CSF) and its receptors in embryo and endometrium implicates the involvement of this glycoprotein on implantation process. In the present study, we aimed to evaluate the impact of routine use of subcutaneous administration of G-CSF on pregnancy outcomes in intracytoplasmic sperm injection (ICSI) patients. <strong...
متن کاملImprovement in Development and Quality of 8 Cell Mouse Embryos in Presence of Granulocyte Macrophage-Colony Stimulating Factor
Purpose: Granulose Macrophage-Colony Stimulating Factor (GM-CSF) is a lympho- heamatopoietic actor, secreted in the reproductive system. Murine pre- implantation embryos express GM-CSF receptors. In his study, the capacity of eight cell mouse embryos was studied in the presence and absence of GM-CSF. Materials and Methods: Female NMRI mice were super ovulated using Pregnant Mare Serum gonadotr...
متن کاملP-108: Efficacy of Intrauterine Injection of Granulocyte Colony Stimulating Factor on Treatment of Unexplained Recurrent Miscarriage
Background Effects of GCSF (Granulocyte Colony-stimulating Factor) injection in patients suffering from recurrent pregnancy loss has been studied in some studies and we now know that transvaginal perfusion of G-CSF might be helpful for improvement of implantation rate among patients with thin endometrium and patients under in vitro fertilization /embryo transfer (IVF/ET) or intracytoplasmic spe...
متن کاملP-214: Parental Contribution of HLA-G*0106 and G*0105N to Repeated Implantation Failure
Background: HLA-G, as a tolerogenic molecule, expressed in cytotrophoblast cells and playing an important role in the suppression of the immune response in maternal decidua. Today Interaction of the extracellular domains of HLA-G protein with cell receptors of immune system, including CD8, LILRB1, LILRB2 and killer cell immunoglobulin-like receptor KIR2DL4, was well known. Materials and Methods...
متن کاملP-76: Important Role of Macrophage Colony-Stimulating Factor during Menstrual Cycle and Early Pregnancy Phase in Oovarian Stimulated IVF-Ppatients
Background: M-CSF is a cytokine mediating the growth, proliferation and differentiation of various cell types including macrophages, trophoblast cells, and osteoclasts. It plays an important role in immunity reproduction, follicle development and ovulation. In the present study, we describe the important role of the changes in serum M-CSF levels during the menstrual cycle, in the process of fol...
متن کامل